Product Name :
TSSC3 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
Beckwith Wiedemann syndrome chromosome region 1 candidate protein C antibody Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein antibody BRW 1C antibody BRW1C antibody BWR 1C antibody BWR1C antibody HLDA 2 antibody HLDA2 antibody Imprinted in placenta and liver antibody Imprinted in placenta and liver protein antibody 展开
Function :
TSSC3 (Tumor-suppressing STF cDNA 3 protein), also known as PHLDA2 (pleckstrin homology-like domain family A member 2), BWR1C, HLDA2 or IPL, is a cytoplasmic protein that is involved in fetal and placental growth. Expressed at high levels in placenta and adult prostate and at low levels in liver, lung and brain, TSSC3 is an apoptosis-related protein that acts as a negative growth regulator and is expressed during normal human development. TSSC3, a protein expressed from the maternal allele, is imprinted on placenta, liver and fetal tissues during embryogenesis and is removed once development is complete. Defects or alterations in the gene encoding TSSC3 are associated with several afflictions such as lung, ovarian and breast cancer, rhabdomyosarcoma, Beckwith-Wiedemann syndrome, Wilms tumor, low birth weight and adrenocortical carcinoma. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human TSSC3 31-80/152
Species reactivity:
Human, Mouse, Rat, Chicken, Pig, Cow, Horse
Verify application:
WB, ELISA, IHC-P, IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year.1107658-78-5 In stock Avoid repeated freeze/thaw cycles.2-Aminoimidazole Formula The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃.PMID:33544204 When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
17 KDa
Positive control :
Expressed in placenta and adult prostate gland.