Product Name :
RAN Mouse Monoclonal Antibody [A1-6D]
Predicted band size :
Observed band size :
Synonyms:
Androgen receptor associated protein 24 antibody Androgen receptor-associated protein 24 antibody ARA 24 antibody ARA24 antibody Gsp1 antibody GTP binding nuclear protein RAN antibody GTP-binding nuclear protein Ran antibody GTPase Ran antibody Guanosine triphosphatase Ran antibody LPS antibody 展开
Function :
The small Ras-related protein Ran, also called TC4, is a nuclear localized GTPase implicated in a diverse array of cellular processes including DNA replication, entry into and exit from mitosis and the transport of RNA and proteins through the nuclear pore complex. Like Ras, active Ran GTP and inactive Ran GDP levels are tightly regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). The abundant GEF, RCC1 (regulator of chromosome condensation 1), increases the rate at which Ran exchanges GDP for GTP. Ran GAP1 opposes the effects of RCC1 by increasing the rate at which Ran hydrolyzes GTP to GDP. A protein designated Ran BP1 has no intrinsic GAP activity, and functions as a GEF inhibitor deactivating RCC1 and thereby indirectly increasing the ratio of Ran GDP to Ran GTP. The Ran BP2 protein has been proposed as the Ran GTP docking site at the periphery of the nuclear pore complex.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Recombinant protein
Species reactivity:
Human, Mouse, Monkey, Rat
Verify application:
WB, IHC-P, ICC, FC
Coupling :
unconjugated
Clone number:
A1-6D
RRID:
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
4℃; -20℃ for long term storage.1319716-41-0 Purity
Storage buffer solution:
Purified antibody in PBS with 0.(S)-2-Methylpiperidine hydrochloride Price 05% sodium azide.PMID:33468536
Subtype:
IgG1
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
25 kDa
Positive control :
Human RAN recombinant protein, RAN-hIgGFc transfected HEK293 cell lysate, Hela, NIH/3T3, A431, C6, Jurkat, Hela, COS7, and Jurkat cell lysate, GC-7901, HepG2, human cervical cancer tissue, human stomach cancer tissue.