PAX3 Mouse Monoclonal Antibody [G7-D8]

Function :
Pax genes contain paired domains that share strong homology to genes in Drosophila which are involved in programming early development. The product of the Pax-3 gene is a DNA-binding protein expressed during early neurogenesis. Pax-3 is a protein containing both a paired domain and a paired-type homeodomain. During early neurogenesis, Pax-3 expression is limited to mitotic cells in the ventricular zone of the developing spinal cord and to distinct regions in the hindbrain, midbrain and diencephalon. In 10-12 day embryos, expression of Pax-3 is also seen in neural crest cells of the developing spinal ganglia, the craniofacial mesectoderm and in limb mesenchyme. Mutations in the MITF and Pax-3 genes, encoding transcriptions factors, are responsible for Waardenburg syndrome II (WS2) and WS1/WS3, respectively. Pax-7 is a gene specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization revealed that Pax-7 is also expressed in satellite cells residing in adult muscle. The gene which encodes Pax-7 maps to human chromosome 1p36.2-p36.12.