Product Name :
WAS Mouse Monoclonal Antibody [E10-4B]
Predicted band size :
Observed band size :
Synonyms:
Eczema thrombocytopenia antibody IMD2 antibody SCNX antibody THC antibody THC1 antibody Thrombocytopenia 1 (X linked) antibody U42471 antibody Was antibody WASp antibody WASP_HUMAN antibody 展开
Function :
The Wiskott-Aldrich syndrome (WAS) is a disorder that results from a monogenic defect that has been mapped to the short arm of the X chromosome. WAS is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity and a propensity for lymphoproliferative disease. The gene that is mutated in the syndrome encodes a proline-rich protein of unknown function designated WAS protein (WASP). A clue to WASP function came from the observation that T cells from affected males had an irregular cellular morphology and a disarrayed cytoskeleton suggesting the involvement of WASP in cytoskeletal organization.Cubane-1-carboxylic acid site Close examination of the WASP sequence revealed a putative Cdc42/Rac interacting domain, homologous with those found in PAK65 and ACK. Subsequent investigation has shown WASP to be a true downstream effector of Cdc42.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Recombinant protein
Species reactivity:
Human
Verify application:
WB, IHC-P, FC
Coupling :
unconjugated
Clone number:
E10-4B
RRID:
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
4℃; -20℃ for long term storage.1251013-26-9 structure
Storage buffer solution:
Purified antibody in PBS with 0.PMID:33464403 05% sodium azide.
Subtype:
IgG2a
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
53 kDa
Positive control :
Human WASp recombinant protein, WASp-hIgGFc transfected HEK293 cell lysate, human ovarian cancer tissue, human colon cancer tissue, Hela.