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Understanding the processes that initiate and terminate critical periods for receptive field plasticity is often a subject of intense investigation.Price of 387859-70-3 The initiation in the vital period for ocular dominance plasticity is extensively believed to become triggered by the maturation of inhibitory synapses targeting the somata of principal neurons inside the visual cortex (Hensch et al.2-(Pyrrolidin-3-yl)acetic acid Formula , 1998; Huang et al.PMID:33723572 , 1999; Di Cristo et al., 2007). Enhanced perisomatic inhibition would lower excitability in principal neurons, enabling mechanisms of activity-dependent synaptic plasticity to discriminate involving inputs in the two eyes (Jiang et al., 2007; Toyoizumi and Miller, 2009; Kuhlman et al., 2010). The activation of inhibitory GABA receptors would also limit activity at NMDA receptors and restrict subsequent induction of synaptic plasticity at excitatory synapses onto principal neurons (Kirkwood and Bear, 1994; Rozas et al., 2001; Artola and Singer, 1987; Jang et al., 2009).?2013 Elsevier Inc. All rights reserved. Correspondence to: [email protected]. Equally contributing very first authors Publisher’s Disclaimer: This can be.