Product Name :
PKM2 Rabbit Polyclonal Antibody
Predicted band size :
58 kDa
Observed band size :
58 kDa
Synonyms:
CTHBP antibody Cytosolic thyroid hormone binding protein antibody Cytosolic thyroid hormone-binding protein antibody KPYM_HUMAN antibody MGC3932 antibody OIP 3 antibody OIP-3 antibody OIP3 antibody OPA interacting protein 3 antibody Opa-interacting protein 3 antibody 展开
Function :
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival . Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity).
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Recombinant protein corresponding to C terminal of Human PKM2 .
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
AB_3073410
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.1639-66-3 Chemscene
Storage buffer solution:
1*PBS (pH7.2749963-99-1 Chemical name 4), 0.PMID:33599247 2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 58 kDa
Positive control :
MDA-MB-231 cell lysate, SiHa cell lysate, NIH/3T3 cell lysate, Rat heart tissue lysate, Rat skeletal muscle tissue lysate, A549, NIH/3T3, PC-12, human lung cancer tissue, human testis tissue, mouse testis tissue, rat testis tissue.